Recommended dosage Zyloprim

Consumer Information (PDR)

ADULTS

Your doctor will tailor the dosage of Zyloprim individually to control the severity of symptoms and to bring the uric acid levels to normal or near normal.

Gout

The usual starting dose is 100 milligrams once daily. Your doctor may increase your dose by 100 milligrams per day at 1-week intervals until desired results are attained. The average dose is 200 to 300 milligrams per day for mild gout and 400 to 600 milligrams daily for moderate to severe gout. The most you should take in a day is 800 milligrams.

Recurrent Kidney Stones

The usual dose is 200 to 300 milligrams daily, divided into smaller doses or taken as one dose.

Management of Uric Acid Levels in Certain Cancers

The usual dose is 600 to 800 milligrams daily for 2 to 3 days, together with a high fluid intake.

CHILDREN

The usual recommended dose for children 6 to 10 years of age is 300 milligrams daily for the management of uric acid levels in certain types of cancer. Children under 6 years of age are generally given 150 milligrams daily.

Consumer Information (Cerner Multum)

If this medicine upsets your stomach, it may be taken after meals. If stomach upset (indigestion, nausea, vomiting, diarrhea, or stomach pain) continues, check with your doctor.

In order for this medicine to help you, it must be taken regularly as ordered by your doctor .

To help prevent kidney stones while taking allopurinol, adults should drink at least 10 to 12 full glasses (8 ounces each) of fluids each day unless otherwise directed by their doctor. Check with the doctor about the amount of fluids that children should drink each day while receiving this medicine. Also, your doctor may want you to take another medicine to make your urine less acidic. It is important that you follow your doctor's instructions very carefully.

For patients taking allopurinol for chronic gout :

• After you begin to take allopurinol, gout attacks may continue to occur for a while. However, if you take this medicine regularly as directed by your doctor, the attacks will gradually become less frequent and less painful. After you have been taking allopurinol regularly for several months, the attacks may stop completely.
• Allopurinol is used to help prevent gout attacks. It will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take this medicine also .

Dosing—The dose of allopurinol will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of allopurinol. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets that you take each day and the number of times that you take the medicine every day depend on the strength of the medicine, on the dose that you need, and on the reason you are taking allopurinol. Up to 300 milligrams (mg) of allopurinol can be taken at one time. Doses larger than 300 mg a day should be divided into smaller amounts that are taken two, three, or even four times a day.

• For the oral dosage form (tablets):
  • For gout:
    • Adults—At first, most people will take 100 mg a day. After about a week, your doctor will probably increase the dose gradually until the amount of uric acid in your blood has been lowered to normal levels. The total amount of allopurinol is usually not more than 800 mg a day. After the uric acid has remained at normal levels for a while, your doctor may lower your dose gradually until you are taking the smallest amount of medicine that will keep the uric acid from increasing again.
    • Children and teenagers—Use and dose must be determined by the doctor.
  • For kidney stones:
    • Adults—100 to 800 mg a day, depending on the kind of kidney stones.
    • Children and teenagers—Use and dose must be determined by the doctor.
  • For preventing or treating medical problems that may occur if certain treatments increase the amount of uric acid in the blood:
    • Adults—600 to 800 mg a day, starting one to three days before the treatment.
    • Children—The dose depends on the child's age
      • Children up to 6 years of age: 50 mg (one-half of a 100-mg tablet) three times a day.
      • Children 6 to 10 years of age: One 100-mg tablet three times a day or one 300-mg tablet a day.
      • Children 11 years of age and older: The dose may be the same as for adults.

• For the parenteral dosage form (injection):
  • For preventing or treating medical problems that may occur if certain treatments increase the amount of uric acid in the blood:
    • Adults—200 to 400 mg per square meter of body surface area (mg/m² ) a day, injected into a vein. Starting one to two days before treatment, this dose may be given as a single dose or divided into smaller doses as determined by your doctor. Your doctor will check your uric acid level and may change your dose based on the level. However, the dose is usually not more than 600 mg per day.
    • Children—At first, 200 mg per square meter of body surface area (mg/m² ) per day, injected into a vein. Starting one to two days before treatment, this dose may be given as a single dose or divided into smaller doses as determined by your doctor . Your doctor will check your uric acid level and may change your dose based on the level.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.